Drug interactions
Lefamulin + Olanzapine
Severity: Moderate
Lefamulin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and olanzapine may add a small further effect. The combination may increase the risk of torsade de pointes, particularly with electrolyte disturbance or heart disease.
What this interaction means in plain words
Lefamulin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Olanzapine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QT interval.
What to do
Use an alternative antibiotic if the patient has other QT risk factors. Otherwise obtain an ECG and correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Olanzapine?
MediHelp rates the interaction as moderate. Lefamulin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval, and olanzapine may add a small further effect. The combination may increase the risk of torsade de pointes, particularly with electrolyte disturbance or heart disease.
How serious is the interaction between Lefamulin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if the patient has other QT risk factors. Otherwise obtain an ECG and correct potassium and magnesium before and during therapy.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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