Drug interactions
Lefamulin + Salbutamol
Severity: Moderate
Lefamulin and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, and salbutamol may add to this effect, especially at high doses or with low potassium. The combination is relevant mainly in patients with other proarrhythmic risk factors.
What this interaction means in plain words
Lefamulin and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia as a possible contributor.
What to do
Monitor ECG and correct hypokalemia and hypomagnesemia in patients with cardiac risk factors. Consider an alternative antibiotic if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Salbutamol?
MediHelp rates the interaction as moderate. Lefamulin and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval, and salbutamol may add to this effect, especially at high doses or with low potassium. The combination is relevant mainly in patients with other proarrhythmic risk factors.
How serious is the interaction between Lefamulin and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct hypokalemia and hypomagnesemia in patients with cardiac risk factors. Consider an alternative antibiotic if QT risk is high.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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