Drug interactions
Lefamulin + Zolpidem
Severity: Moderate
Lefamulin and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is expected to raise zolpidem exposure, increasing sedation, next-day impairment and complex sleep behaviors.
What this interaction means in plain words
Lefamulin and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Zolpidem belongs to Central Nervous System.
Why it happens
Lefamulin inhibits CYP3A4, which contributes to zolpidem metabolism.
What to do
Monitor for excessive sedation and impaired psychomotor function. Consider lowering the zolpidem dose during lefamulin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Other interactions of Zolpidem
Frequently asked questions
Can I take Lefamulin with Zolpidem?
MediHelp rates the interaction as moderate. Lefamulin and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin is expected to raise zolpidem exposure, increasing sedation, next-day impairment and complex sleep behaviors.
How serious is the interaction between Lefamulin and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and impaired psychomotor function. Consider lowering the zolpidem dose during lefamulin therapy.
What other medicines interact with Lefamulin?
MediHelp also lists interactions of Lefamulin with, for example, Methadone, Pimavanserin, Pimozide. The full list is on the Lefamulin page.
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