Drug interactions
Letibotulinumtoxina + Streptomycin
Severity: Moderate
Letibotulinumtoxina and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can impair neuromuscular transmission and may potentiate the effect of botulinum toxin. This could produce excessive or generalized muscle weakness, including swallowing or breathing difficulty.
What this interaction means in plain words
Letibotulinumtoxina and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade, with aminoglycoside inhibition of presynaptic acetylcholine release complementing toxin activity.
What to do
Avoid starting streptomycin around the time of toxin injection when possible. If both are needed, monitor for generalized weakness, dysphagia and respiratory compromise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Letibotulinumtoxina with Streptomycin?
MediHelp rates the interaction as moderate. Letibotulinumtoxina and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can impair neuromuscular transmission and may potentiate the effect of botulinum toxin. This could produce excessive or generalized muscle weakness, including swallowing or breathing difficulty.
How serious is the interaction between Letibotulinumtoxina and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting streptomycin around the time of toxin injection when possible. If both are needed, monitor for generalized weakness, dysphagia and respiratory compromise.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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