Drug interactions
Levalbuterol + Methadone
Severity: Minor
Levalbuterol and Methadone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No meaningful sedative interaction is established. Beta-agonists may cause hypokalemia and minor QT effects, which could slightly add to methadone risk at high doses.
What this interaction means in plain words
Levalbuterol and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2 agonist-induced hypokalemia and tachycardia may modestly add to methadone QT prolongation.
What to do
No action is routinely needed. Check potassium and ECG in patients on high-dose methadone using frequent or high-dose levalbuterol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Levalbuterol with Methadone?
MediHelp rates the interaction as minor. Levalbuterol and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No meaningful sedative interaction is established. Beta-agonists may cause hypokalemia and minor QT effects, which could slightly add to methadone risk at high doses.
How serious is the interaction between Levalbuterol and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is routinely needed. Check potassium and ECG in patients on high-dose methadone using frequent or high-dose levalbuterol.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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