Drug interactions
levodopa + phenelzine (nonselective maoi)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hypertensive crisis risk.
Mechanism of action
Excess catecholamines.
Clinical management
Avoid; if needed, use selective MAO-B at low doses with care.
References
Frequently asked questions
Can I take levodopa with phenelzine (nonselective maoi)?
The interaction is rated: Major. Hypertensive crisis risk.
How serious is the interaction between levodopa and phenelzine (nonselective maoi)?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between levodopa and phenelzine (nonselective maoi) managed?
Avoid; if needed, use selective MAO-B at low doses with care.
Why do levodopa and phenelzine (nonselective maoi) interact?
Excess catecholamines.
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