Drug interactions
Levodopa inhaled + Rasagiline
Severity: Moderate
Levodopa inhaled and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is commonly combined with levodopa and enhances its dopaminergic effect. The combination can increase dyskinesia, nausea and orthostatic hypotension, and levodopa may need dose reduction.
What this interaction means in plain words
Levodopa inhaled and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO-B inhibition reduces dopamine breakdown, so the effects of levodopa-derived dopamine are additive.
What to do
Monitor orthostatic blood pressure and dyskinesia when starting or adjusting either drug. Reduce the levodopa dose if dopaminergic adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Levodopa inhaled with Rasagiline?
MediHelp rates the interaction as moderate. Levodopa inhaled and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is commonly combined with levodopa and enhances its dopaminergic effect. The combination can increase dyskinesia, nausea and orthostatic hypotension, and levodopa may need dose reduction.
How serious is the interaction between Levodopa inhaled and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and dyskinesia when starting or adjusting either drug. Reduce the levodopa dose if dopaminergic adverse effects occur.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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