Drug interactions
Levodopa inhaled + Selegiline
Severity: Moderate
Levodopa inhaled and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa with nonselective MAO inhibition can cause hypertensive reactions. Selegiline is MAO-B selective at low oral doses and is commonly combined with levodopa, but selectivity is lost at higher oral doses or with transdermal use.
What this interaction means in plain words
Levodopa inhaled and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nonselective MAO inhibition prevents catecholamine breakdown from levodopa-derived dopamine, raising the risk of a pressor response.
What to do
Keep oral selegiline at selective doses and monitor blood pressure. Avoid transdermal selegiline or higher doses with levodopa.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Levodopa inhaled with Selegiline?
MediHelp rates the interaction as moderate. Levodopa inhaled and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa with nonselective MAO inhibition can cause hypertensive reactions. Selegiline is MAO-B selective at low oral doses and is commonly combined with levodopa, but selectivity is lost at higher oral doses or with transdermal use.
How serious is the interaction between Levodopa inhaled and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep oral selegiline at selective doses and monitor blood pressure. Avoid transdermal selegiline or higher doses with levodopa.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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