Drug interactions
Albuterol + Levofloxacin
Severity: Moderate
Albuterol and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QT interval, and high-dose or systemic albuterol can cause hypokalemia and tachycardia, which promote arrhythmia. Together they may increase the risk of QT-related arrhythmias, mainly with nebulized or frequent dosing.
What this interaction means in plain words
Albuterol and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects: fluoroquinolone QT prolongation plus beta-agonist-induced hypokalemia and increased heart rate.
What to do
Monitor potassium and ECG in patients using high-dose or nebulized albuterol with levofloxacin, especially with other QT risk factors. Correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Albuterol with Levofloxacin?
MediHelp rates the interaction as moderate. Albuterol and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can prolong the QT interval, and high-dose or systemic albuterol can cause hypokalemia and tachycardia, which promote arrhythmia. Together they may increase the risk of QT-related arrhythmias, mainly with nebulized or frequent dosing.
How serious is the interaction between Albuterol and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and ECG in patients using high-dose or nebulized albuterol with levofloxacin, especially with other QT risk factors. Correct hypokalemia promptly.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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