Drug interactions
Levonorgestrel + Metformin-sitagliptin
Severity: Minor
Levonorgestrel and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly impair glucose tolerance in some patients. With levonorgestrel, particularly at emergency contraception or low-dose levels, this seldom changes glycemic control meaningfully.
What this interaction means in plain words
Levonorgestrel and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Progestins may slightly reduce insulin sensitivity, opposing the glucose-lowering effect of metformin and sitagliptin.
What to do
No routine change is needed; review glucose control at regular follow-up in women with diabetes starting or stopping levonorgestrel.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Levonorgestrel and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly impair glucose tolerance in some patients. With levonorgestrel, particularly at emergency contraception or low-dose levels, this seldom changes glycemic control meaningfully.
How serious is the interaction between Levonorgestrel and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; review glucose control at regular follow-up in women with diabetes starting or stopping levonorgestrel.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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