Drug interactions
Levonorgestrel + Mobocertinib
Severity: Major
Levonorgestrel and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib may reduce hormonal contraceptive exposure, which could cause contraceptive failure or breakthrough bleeding. Fetal risk makes this significant.
What this interaction means in plain words
Levonorgestrel and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mobocertinib is a CYP3A4 inducer that increases progestin metabolism.
What to do
Use an effective non-hormonal contraceptive during therapy and for the period recommended in labeling afterward.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Mobocertinib?
MediHelp rates the interaction as major. Levonorgestrel and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib may reduce hormonal contraceptive exposure, which could cause contraceptive failure or breakthrough bleeding. Fetal risk makes this significant.
How serious is the interaction between Levonorgestrel and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive during therapy and for the period recommended in labeling afterward.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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