Drug interactions
Levonorgestrel + Mycophenolate
Severity: Moderate
Levonorgestrel and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate labeling reports a modest fall in levonorgestrel exposure when given with an oral contraceptive. Because mycophenolate is teratogenic, any loss of contraceptive reliability is important.
What this interaction means in plain words
Levonorgestrel and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; the interaction may involve altered progestin metabolism or disposition.
What to do
Use an additional or alternative reliable contraceptive method as required by mycophenolate pregnancy-prevention programs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Mycophenolate?
MediHelp rates the interaction as moderate. Levonorgestrel and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate labeling reports a modest fall in levonorgestrel exposure when given with an oral contraceptive. Because mycophenolate is teratogenic, any loss of contraceptive reliability is important.
How serious is the interaction between Levonorgestrel and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional or alternative reliable contraceptive method as required by mycophenolate pregnancy-prevention programs.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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