Drug interactions
Levonorgestrel + Valoctocogene roxaparvovec
Severity: Moderate
Levonorgestrel and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec can cause raised liver enzymes, and hepatotoxic or hepatically active drugs may add to this. Hormonal contraceptives have been noted as a potential concern in the gene therapy labeling.
What this interaction means in plain words
Levonorgestrel and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Possible additive hepatic stress; a defined pharmacokinetic mechanism is not established.
What to do
Monitor ALT and other liver tests per the gene therapy protocol and review the need for hormonal contraception with the hematology team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Levonorgestrel with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Levonorgestrel and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec can cause raised liver enzymes, and hepatotoxic or hepatically active drugs may add to this. Hormonal contraceptives have been noted as a potential concern in the gene therapy labeling.
How serious is the interaction between Levonorgestrel and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT and other liver tests per the gene therapy protocol and review the need for hormonal contraception with the hematology team.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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