Drug interactions
Levonorgestrel intrauterine + Metformin-pioglitazone
Severity: Minor
Levonorgestrel intrauterine and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intrauterine levonorgestrel has low systemic exposure and a minimal effect on glucose metabolism. A clinically relevant loss of diabetes control is unlikely.
What this interaction means in plain words
Levonorgestrel intrauterine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestins can slightly reduce insulin sensitivity, but systemic exposure from the intrauterine system is low.
What to do
No change in antidiabetic therapy is normally needed; monitor glucose as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Levonorgestrel intrauterine with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Levonorgestrel intrauterine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intrauterine levonorgestrel has low systemic exposure and a minimal effect on glucose metabolism. A clinically relevant loss of diabetes control is unlikely.
How serious is the interaction between Levonorgestrel intrauterine and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in antidiabetic therapy is normally needed; monitor glucose as part of routine care.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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