Drug interactions
Levonorgestrel intrauterine + Oxcarbazepine
Severity: Minor
Levonorgestrel intrauterine and Oxcarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine reduces hormonal contraceptive exposure, but the intrauterine system acts mainly locally with low systemic levels, so contraceptive efficacy is largely maintained.
What this interaction means in plain words
Levonorgestrel intrauterine and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction may lower systemic levonorgestrel, but local endometrial concentrations remain high.
What to do
No change is generally needed for the intrauterine system. Avoid relying on oral progestin-only methods alone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Levonorgestrel intrauterine with Oxcarbazepine?
MediHelp rates the interaction as minor. Levonorgestrel intrauterine and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine reduces hormonal contraceptive exposure, but the intrauterine system acts mainly locally with low systemic levels, so contraceptive efficacy is largely maintained.
How serious is the interaction between Levonorgestrel intrauterine and Oxcarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is generally needed for the intrauterine system. Avoid relying on oral progestin-only methods alone.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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