Drug interactions
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate + Morphine
Severity: Minor
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives may increase morphine glucuronidation, which could slightly lower morphine exposure. The effect is small and of uncertain clinical significance.
What this interaction means in plain words
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible induction of UGT-mediated glucuronidation by ethinylestradiol; not firmly established.
What to do
No dose change is routinely needed; assess analgesic response and titrate morphine if pain control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate with Morphine?
MediHelp rates the interaction as minor. Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogen-containing contraceptives may increase morphine glucuronidation, which could slightly lower morphine exposure. The effect is small and of uncertain clinical significance.
How serious is the interaction between Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; assess analgesic response and titrate morphine if pain control is inadequate.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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