Drug interactions
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate + Paracetamol
Severity: Minor
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Paracetamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paracetamol may modestly raise ethinylestradiol exposure by competing for sulfation, while estrogen-containing contraceptives can increase paracetamol clearance through glucuronidation induction. The changes are usually small and rarely clinically important.
What this interaction means in plain words
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Paracetamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for sulfate conjugation of ethinylestradiol by paracetamol, and estrogen-related induction of paracetamol glucuronidation.
What to do
No routine adjustment is needed with usual paracetamol doses. If analgesic response to paracetamol seems reduced, review the dose within the maximum daily limit.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Felbamate + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
Frequently asked questions
Can I take Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate with Paracetamol?
MediHelp rates the interaction as minor. Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Paracetamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paracetamol may modestly raise ethinylestradiol exposure by competing for sulfation, while estrogen-containing contraceptives can increase paracetamol clearance through glucuronidation induction. The changes are usually small and rarely clinically important.
How serious is the interaction between Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Paracetamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed with usual paracetamol doses. If analgesic response to paracetamol seems reduced, review the dose within the maximum daily limit.
What other medicines interact with Paracetamol?
MediHelp also lists interactions of Paracetamol with, for example, Ethanol, Busulfan, Carbamazepine. The full list is on the Paracetamol page.
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