Drug interactions
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate + Vitamin c
Severity: Minor
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Vitamin c: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose ascorbic acid has been reported to raise ethinylestradiol exposure, probably by competing for sulfation in the gut wall. The effect is generally small and unlikely to matter at dietary or ordinary supplement doses.
What this interaction means in plain words
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Vitamin c have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competitive inhibition of ethinylestradiol sulfation in the intestinal wall by ascorbic acid, increasing bioavailability.
What to do
No change is usually needed. Be aware of estrogenic adverse effects such as breast tenderness or nausea if the patient takes very high-dose vitamin C.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin c
Frequently asked questions
Can I take Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate with Vitamin c?
MediHelp rates the interaction as minor. Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Vitamin c have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose ascorbic acid has been reported to raise ethinylestradiol exposure, probably by competing for sulfation in the gut wall. The effect is generally small and unlikely to matter at dietary or ordinary supplement doses.
How serious is the interaction between Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Vitamin c?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is usually needed. Be aware of estrogenic adverse effects such as breast tenderness or nausea if the patient takes very high-dose vitamin C.
What other medicines interact with Vitamin c?
MediHelp also lists interactions of Vitamin c with, for example, Deferoxamine, Aluminum hydroxide, Dextroamphetamine transdermal. The full list is on the Vitamin c page.
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