Drug interactions
Levorphanol + Lofexidine
Severity: Moderate
Levorphanol and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a potent opioid, and together with lofexidine it can increase sedation, hypotension and respiratory depression. The risk is greatest at higher opioid doses or in opioid-naive patients.
What this interaction means in plain words
Levorphanol and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and central alpha-2 stimulation.
What to do
Monitor sedation, respiratory rate and blood pressure, and titrate each drug carefully. Reduce doses if oversedation or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Levorphanol with Lofexidine?
MediHelp rates the interaction as moderate. Levorphanol and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levorphanol is a potent opioid, and together with lofexidine it can increase sedation, hypotension and respiratory depression. The risk is greatest at higher opioid doses or in opioid-naive patients.
How serious is the interaction between Levorphanol and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and blood pressure, and titrate each drug carefully. Reduce doses if oversedation or hypotension develops.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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