Drug interactions
Levosalbutamol + Salmeterol
Severity: Moderate
Levosalbutamol and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two beta-2 agonists duplicates therapy and can add to tachycardia, tremor, hypokalemia and arrhythmia risk. Levosalbutamol is typically used as short-acting rescue therapy alongside salmeterol, but frequent need for it signals poor control.
What this interaction means in plain words
Levosalbutamol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levosalbutamol belongs to Respiratory; Salmeterol belongs to Respiratory.
Why it happens
Additive beta-2 adrenergic receptor stimulation causing cardiovascular effects and potassium shift into cells.
What to do
Limit levosalbutamol to as-needed rescue use and review asthma control if use is frequent. Monitor heart rate and serum potassium in patients with cardiac disease or high doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Levosalbutamol with Salmeterol?
MediHelp rates the interaction as moderate. Levosalbutamol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two beta-2 agonists duplicates therapy and can add to tachycardia, tremor, hypokalemia and arrhythmia risk. Levosalbutamol is typically used as short-acting rescue therapy alongside salmeterol, but frequent need for it signals poor control.
How serious is the interaction between Levosalbutamol and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit levosalbutamol to as-needed rescue use and review asthma control if use is frequent. Monitor heart rate and serum potassium in patients with cardiac disease or high doses.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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