Drug interactions
Levosalbutamol + Spironolactone
Severity: Minor
Levosalbutamol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levosalbutamol lowers serum potassium by driving it into cells while spironolactone promotes potassium retention. The effects largely offset each other, but potassium may vary in renal impairment.
What this interaction means in plain words
Levosalbutamol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levosalbutamol belongs to Respiratory; Spironolactone belongs to Cardiovascular.
Why it happens
Beta2-mediated potassium shift opposes aldosterone antagonism-related potassium retention.
What to do
No routine adjustment is needed. Monitor potassium in renal impairment, heart failure or with high-dose levosalbutamol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levosalbutamol and Spironolactone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Levosalbutamol
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Levosalbutamol with Spironolactone?
MediHelp rates the interaction as minor. Levosalbutamol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levosalbutamol lowers serum potassium by driving it into cells while spironolactone promotes potassium retention. The effects largely offset each other, but potassium may vary in renal impairment.
How serious is the interaction between Levosalbutamol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor potassium in renal impairment, heart failure or with high-dose levosalbutamol.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
