Drug interactions
Lidocaine + Lily of the valley
Severity: Minor
Lidocaine and Lily of the valley: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides that can cause arrhythmias and conduction disturbances. Systemic lidocaine has antiarrhythmic effects and may also affect conduction, but a clinically meaningful interaction is poorly documented.
What this interaction means in plain words
Lidocaine and Lily of the valley have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive cardiac conduction effects; the mechanism is not well established.
What to do
Avoid herbal lily of the valley products. If used with systemic lidocaine, monitor ECG and symptoms of arrhythmia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Lily of the valley?
MediHelp rates the interaction as minor. Lidocaine and Lily of the valley have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lily of the valley contains cardiac glycosides that can cause arrhythmias and conduction disturbances. Systemic lidocaine has antiarrhythmic effects and may also affect conduction, but a clinically meaningful interaction is poorly documented.
How serious is the interaction between Lidocaine and Lily of the valley?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid herbal lily of the valley products. If used with systemic lidocaine, monitor ECG and symptoms of arrhythmia.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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