Drug interactions
Lidocaine + Olaparib
Severity: Minor
Lidocaine and Olaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is metabolized by CYP3A4, and moderate or strong inhibitors raise its exposure. Lidocaine is only a weak inhibitor, so a clinically significant increase is unlikely.
What this interaction means in plain words
Lidocaine and Olaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Olaparib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by lidocaine may slightly reduce olaparib metabolism.
What to do
No dose change is needed; monitor for olaparib hematologic toxicity as part of routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Lidocaine with Olaparib?
MediHelp rates the interaction as minor. Lidocaine and Olaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olaparib is metabolized by CYP3A4, and moderate or strong inhibitors raise its exposure. Lidocaine is only a weak inhibitor, so a clinically significant increase is unlikely.
How serious is the interaction between Lidocaine and Olaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for olaparib hematologic toxicity as part of routine care.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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