Drug interactions
Lidocaine + Opium tincture
Severity: Minor
Lidocaine and Opium tincture: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture contains morphine and causes sedation and respiratory depression. Systemic lidocaine may add to CNS depression, mainly at high or intravenous doses.
What this interaction means in plain words
Lidocaine and Opium tincture have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS and respiratory depression.
What to do
Monitor sedation and respiratory rate when systemic lidocaine is used, and reduce the opium dose if oversedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Opium tincture?
MediHelp rates the interaction as minor. Lidocaine and Opium tincture have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opium tincture contains morphine and causes sedation and respiratory depression. Systemic lidocaine may add to CNS depression, mainly at high or intravenous doses.
How serious is the interaction between Lidocaine and Opium tincture?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate when systemic lidocaine is used, and reduce the opium dose if oversedation occurs.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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