Drug interactions
Lidocaine + Pentobarbital
Severity: Moderate
Lidocaine and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may increase lidocaine clearance, lowering its effect. The magnitude is variable and more relevant with chronic barbiturate use and systemic lidocaine. Additive CNS depression is also possible.
What this interaction means in plain words
Lidocaine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic CYP enzymes (including CYP3A4 and CYP1A2) increases lidocaine metabolism.
What to do
Monitor for reduced antiarrhythmic or anesthetic effect and titrate lidocaine to response, using concentrations if available. Watch for additive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Pentobarbital?
MediHelp rates the interaction as moderate. Lidocaine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and may increase lidocaine clearance, lowering its effect. The magnitude is variable and more relevant with chronic barbiturate use and systemic lidocaine. Additive CNS depression is also possible.
How serious is the interaction between Lidocaine and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiarrhythmic or anesthetic effect and titrate lidocaine to response, using concentrations if available. Watch for additive sedation.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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