Drug interactions
Lidocaine + Pindolol
Severity: Moderate
Lidocaine and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can lower hepatic blood flow and reduce lidocaine clearance, raising its levels. Pindolol also has additive effects on cardiac conduction, so bradycardia and hypotension are possible with systemic lidocaine. The legacy comment about epinephrine concerns epinephrine-containing anesthetic rather than lidocaine itself.
What this interaction means in plain words
Lidocaine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced hepatic blood flow from beta-blockade lowers lidocaine clearance, with additive negative chronotropic and conduction effects.
What to do
Monitor heart rate, blood pressure and ECG during systemic lidocaine, and reduce infusion rate if bradycardia or toxicity appears. Do not stop chronic beta-blocker therapy abruptly before anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Pindolol?
MediHelp rates the interaction as moderate. Lidocaine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can lower hepatic blood flow and reduce lidocaine clearance, raising its levels. Pindolol also has additive effects on cardiac conduction, so bradycardia and hypotension are possible with systemic lidocaine. The legacy comment about epinephrine concerns epinephrine-containing anesthetic rather than lidocaine itself.
How serious is the interaction between Lidocaine and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during systemic lidocaine, and reduce infusion rate if bradycardia or toxicity appears. Do not stop chronic beta-blocker therapy abruptly before anesthesia.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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