Drug interactions
Lidocaine + Pipemidic acid
Severity: Moderate
Lidocaine and Pipemidic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pipemidic acid inhibits CYP1A2, the main enzyme that metabolizes lidocaine, and may therefore raise lidocaine levels. This could lead to toxicity with systemic or repeated dosing.
What this interaction means in plain words
Lidocaine and Pipemidic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2 by pipemidic acid decreases lidocaine metabolism.
What to do
Monitor for lidocaine toxicity such as dizziness, paresthesia, tremor and arrhythmia when systemic doses are used, and reduce dose if needed. Local anesthetic doses usually need no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Pipemidic acid?
MediHelp rates the interaction as moderate. Lidocaine and Pipemidic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pipemidic acid inhibits CYP1A2, the main enzyme that metabolizes lidocaine, and may therefore raise lidocaine levels. This could lead to toxicity with systemic or repeated dosing.
How serious is the interaction between Lidocaine and Pipemidic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lidocaine toxicity such as dizziness, paresthesia, tremor and arrhythmia when systemic doses are used, and reduce dose if needed. Local anesthetic doses usually need no change.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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