Drug interactions
Lidocaine + Ponatinib
Severity: Minor
Lidocaine and Ponatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein in vitro and may modestly raise exposure to P-gp substrates. The effect on lidocaine is expected to be small.
What this interaction means in plain words
Lidocaine and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Ponatinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by ponatinib may decrease lidocaine efflux.
What to do
No routine adjustment is needed at local anesthetic doses. For systemic lidocaine, monitor for signs of toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Lidocaine with Ponatinib?
MediHelp rates the interaction as minor. Lidocaine and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponatinib inhibits P-glycoprotein in vitro and may modestly raise exposure to P-gp substrates. The effect on lidocaine is expected to be small.
How serious is the interaction between Lidocaine and Ponatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed at local anesthetic doses. For systemic lidocaine, monitor for signs of toxicity.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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