Drug interactions
Linaclotide + Mosapride
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive prokinetic/secretory effects may precipitate significant diarrhea, abdominal cramping, dehydration, and electrolyte abnormalities.
Mechanism of action
Pharmacodynamic: 5-HT4 agonism (mosapride) increases peristalsis; GC-C activation (linaclotide) increases intestinal secretion and transit, together increasing diarrhea risk.
Clinical management
Avoid routine coadministration. If necessary, start at lowest effective doses, counsel on diarrhea risk, ensure hydration, and hold one agent if diarrhea becomes severe or persistent; check electrolytes if clinically indicated.
Drug reference
References
- Linzess (linaclotide) Prescribing Information — FDA Label
- Prokinetic agents for gastrointestinal motility disorders in adults — UpToDate
Frequently asked questions
Can I take Linaclotide with Mosapride?
The interaction is rated: Moderate. Additive prokinetic/secretory effects may precipitate significant diarrhea, abdominal cramping, dehydration, and electrolyte abnormalities.
How serious is the interaction between Linaclotide and Mosapride?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between Linaclotide and Mosapride managed?
Avoid routine coadministration. If necessary, start at lowest effective doses, counsel on diarrhea risk, ensure hydration, and hold one agent if diarrhea becomes severe or persistent; check electrolytes if clinically indicated.
Why do Linaclotide and Mosapride interact?
Pharmacodynamic: 5-HT4 agonism (mosapride) increases peristalsis; GC-C activation (linaclotide) increases intestinal secretion and transit, together increasing diarrhea risk.
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