Drug interactions
Liotrix + Nateglinide
Severity: Moderate
Liotrix and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones can increase glucose production and metabolic rate, raising blood glucose. This may reduce nateglinide's effectiveness, especially when thyroid dose is increased.
What this interaction means in plain words
Liotrix and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism by thyroid hormone effects on hepatic glucose output and glucose metabolism.
What to do
Monitor blood glucose when thyroid replacement is started or its dose changed. Adjust the antidiabetic regimen if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Liotrix with Nateglinide?
MediHelp rates the interaction as moderate. Liotrix and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase glucose production and metabolic rate, raising blood glucose. This may reduce nateglinide's effectiveness, especially when thyroid dose is increased.
How serious is the interaction between Liotrix and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when thyroid replacement is started or its dose changed. Adjust the antidiabetic regimen if needed.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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