Drug interactions
lisinopril + lithium
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Lithium accumulation → neuro/cardiotoxicity.
Mechanism of action
Reduced renal clearance of lithium with ACEI.
Clinical management
Avoid or monitor lithium levels closely; consider dose reduction.
Drug reference
References
- Lithium interactions — SPS
- ACE inhibitors and lithium — PubMed
Frequently asked questions
Can I take lisinopril with lithium?
The interaction is rated: Major. Lithium accumulation → neuro/cardiotoxicity.
How serious is the interaction between lisinopril and lithium?
The interaction is rated: Major. Evidence level: High.
How is the interaction between lisinopril and lithium managed?
Avoid or monitor lithium levels closely; consider dose reduction.
Why do lisinopril and lithium interact?
Reduced renal clearance of lithium with ACEI.
Full monographs, dosing and an interaction checker in the MediHelp app
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