Drug interactions
Lisinopril + Meclofenamate
Severity: Moderate
Lisinopril and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can reduce the antihypertensive effect of lisinopril and increase the risk of acute kidney injury and hyperkalemia. Risk is greatest in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Lisinopril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibitor effects.
What to do
Use the lowest NSAID dose for the shortest time or choose paracetamol. Monitor blood pressure, creatinine and potassium and keep the patient hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Meclofenamate?
MediHelp rates the interaction as moderate. Lisinopril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can reduce the antihypertensive effect of lisinopril and increase the risk of acute kidney injury and hyperkalemia. Risk is greatest in older, volume-depleted or renally impaired patients.
How serious is the interaction between Lisinopril and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest NSAID dose for the shortest time or choose paracetamol. Monitor blood pressure, creatinine and potassium and keep the patient hydrated.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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