Drug interactions
Lisinopril + Metformin-sitagliptin
Severity: Moderate
Lisinopril and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may lower blood glucose in people taking antidiabetic drugs, so hypoglycemia is occasionally seen. Any ACE inhibitor-related fall in renal function can also reduce metformin clearance and raise the risk of lactic acidosis.
What this interaction means in plain words
Lisinopril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering through enhanced insulin sensitivity, plus possible reduced renal metformin elimination if renal function declines.
What to do
Monitor blood glucose and renal function (eGFR) after starting or changing the ACE inhibitor dose. Reduce or stop metformin-sitagliptin if renal function deteriorates significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Lisinopril and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may lower blood glucose in people taking antidiabetic drugs, so hypoglycemia is occasionally seen. Any ACE inhibitor-related fall in renal function can also reduce metformin clearance and raise the risk of lactic acidosis.
How serious is the interaction between Lisinopril and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function (eGFR) after starting or changing the ACE inhibitor dose. Reduce or stop metformin-sitagliptin if renal function deteriorates significantly.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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