Drug interactions
Lisinopril + Metformin
Severity: Moderate
Lisinopril and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally lead to hypoglycemia in patients with diabetes. They can also reduce renal function in susceptible patients, which may reduce metformin clearance and raise the risk of lactic acidosis.
What this interaction means in plain words
Lisinopril and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Enhanced insulin sensitivity from ACE inhibition plus possible ACE inhibitor-related decline in renal function reducing metformin elimination.
What to do
Monitor blood glucose and renal function (eGFR) regularly, especially after starting or changing the dose. Reduce or stop metformin if renal function declines significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Metformin
Frequently asked questions
Can I take Lisinopril with Metformin?
MediHelp rates the interaction as moderate. Lisinopril and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally lead to hypoglycemia in patients with diabetes. They can also reduce renal function in susceptible patients, which may reduce metformin clearance and raise the risk of lactic acidosis.
How serious is the interaction between Lisinopril and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function (eGFR) regularly, especially after starting or changing the dose. Reduce or stop metformin if renal function declines significantly.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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