Drug interactions
Lisinopril + Mipomersen
Severity: Minor
Lisinopril and Mipomersen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises transaminases and can cause hepatic steatosis, while lisinopril only rarely causes liver injury. Combined use offers little pharmacokinetic basis for interaction, but liver injury from either agent could be harder to attribute.
What this interaction means in plain words
Lisinopril and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established interaction mechanism; possible additive hepatotoxic potential, mainly from mipomersen.
What to do
Follow the mipomersen liver monitoring schedule (ALT, AST, bilirubin) and investigate both drugs if enzymes rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Mipomersen?
MediHelp rates the interaction as minor. Lisinopril and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mipomersen commonly raises transaminases and can cause hepatic steatosis, while lisinopril only rarely causes liver injury. Combined use offers little pharmacokinetic basis for interaction, but liver injury from either agent could be harder to attribute.
How serious is the interaction between Lisinopril and Mipomersen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow the mipomersen liver monitoring schedule (ALT, AST, bilirubin) and investigate both drugs if enzymes rise.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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