Drug interactions
Lisinopril + Moxisylyte
Severity: Moderate
Lisinopril and Moxisylyte: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxisylyte is an alpha-blocking vasodilator and can add to the blood pressure lowering of lisinopril. Patients may experience exaggerated hypotension, dizziness or fainting, particularly after the first dose or when starting either drug.
What this interaction means in plain words
Lisinopril and Moxisylyte can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through alpha-adrenergic blockade and inhibition of angiotensin II formation.
What to do
Start with low doses, advise rising slowly from sitting or lying, and monitor blood pressure after initiation or dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Moxisylyte?
MediHelp rates the interaction as moderate. Lisinopril and Moxisylyte can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxisylyte is an alpha-blocking vasodilator and can add to the blood pressure lowering of lisinopril. Patients may experience exaggerated hypotension, dizziness or fainting, particularly after the first dose or when starting either drug.
How serious is the interaction between Lisinopril and Moxisylyte?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses, advise rising slowly from sitting or lying, and monitor blood pressure after initiation or dose changes.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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