Drug interactions
Lisinopril + Nesiritide
Severity: Moderate
Lisinopril and Nesiritide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nesiritide is a potent intravenous vasodilator whose main adverse effect is hypotension. Added to lisinopril, blood pressure may fall further, with a risk of symptomatic hypotension and reduced renal perfusion.
What this interaction means in plain words
Lisinopril and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilatory and hypotensive effects via natriuretic peptide receptor activation and ACE inhibition.
What to do
Monitor blood pressure frequently during nesiritide infusion and reduce or stop the infusion if hypotension develops; check renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisinopril and Nesiritide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Nesiritide?
MediHelp rates the interaction as moderate. Lisinopril and Nesiritide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nesiritide is a potent intravenous vasodilator whose main adverse effect is hypotension. Added to lisinopril, blood pressure may fall further, with a risk of symptomatic hypotension and reduced renal perfusion.
How serious is the interaction between Lisinopril and Nesiritide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure frequently during nesiritide infusion and reduce or stop the infusion if hypotension develops; check renal function.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
