Drug interactions
Lisinopril + Nitroglycerin rectal
Severity: Moderate
Lisinopril and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal nitroglycerin is absorbed systemically and dilates veins and arteries, which may add to the antihypertensive effect of lisinopril. Lightheadedness, syncope or hypotension can occur, especially in volume-depleted or older patients.
What this interaction means in plain words
Lisinopril and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitric oxide mediated smooth muscle relaxation and ACE inhibition.
What to do
Monitor blood pressure and counsel on postural precautions; lower the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Lisinopril and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal nitroglycerin is absorbed systemically and dilates veins and arteries, which may add to the antihypertensive effect of lisinopril. Lightheadedness, syncope or hypotension can occur, especially in volume-depleted or older patients.
How serious is the interaction between Lisinopril and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel on postural precautions; lower the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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