Drug interactions
Lisinopril + Parecoxib
Severity: Moderate
Lisinopril and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, converted to the COX-2 inhibitor valdecoxib, can blunt the antihypertensive effect of lisinopril. Combined use also raises the risk of acute kidney injury and hyperkalemia, especially with dehydration, in older adults or with existing renal impairment.
What this interaction means in plain words
Lisinopril and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandin synthesis, decreasing vasodilation and sodium excretion and impairing glomerular perfusion.
What to do
Ensure adequate hydration, use the shortest course possible, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Parecoxib?
MediHelp rates the interaction as moderate. Lisinopril and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, converted to the COX-2 inhibitor valdecoxib, can blunt the antihypertensive effect of lisinopril. Combined use also raises the risk of acute kidney injury and hyperkalemia, especially with dehydration, in older adults or with existing renal impairment.
How serious is the interaction between Lisinopril and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration, use the shortest course possible, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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