Drug interactions
Lisinopril + Potassium citrate-citric acid
Severity: Moderate
Lisinopril and Potassium citrate-citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisinopril lowers aldosterone and thus potassium excretion, while potassium citrate adds potassium. Hyperkalemia can develop, with higher risk in renal impairment, diabetes and heart failure.
What this interaction means in plain words
Lisinopril and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Potassium citrate-citric acid belongs to Gastrointestinal Tract.
Why it happens
ACE inhibition decreases aldosterone, reducing renal potassium excretion alongside the supplemental potassium.
What to do
Check potassium and creatinine at baseline and periodically. Decrease or stop the potassium salt if potassium increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisinopril and Potassium citrate-citric acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Potassium citrate-citric acid
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Potassium citrate-citric acid?
MediHelp rates the interaction as moderate. Lisinopril and Potassium citrate-citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisinopril lowers aldosterone and thus potassium excretion, while potassium citrate adds potassium. Hyperkalemia can develop, with higher risk in renal impairment, diabetes and heart failure.
How serious is the interaction between Lisinopril and Potassium citrate-citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and creatinine at baseline and periodically. Decrease or stop the potassium salt if potassium increases.
What other medicines interact with Potassium citrate-citric acid?
MediHelp also lists interactions of Potassium citrate-citric acid with, for example, Amiloride, Eplerenone, Finerenone. The full list is on the Potassium citrate-citric acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
