Drug interactions
Lisinopril + Promazine
Severity: Minor
Lisinopril and Promazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine with alpha-blocking activity that can cause orthostatic hypotension. With lisinopril the blood pressure lowering may be increased.
What this interaction means in plain words
Lisinopril and Promazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when either drug is started or changed, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Promazine?
MediHelp rates the interaction as minor. Lisinopril and Promazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promazine is a phenothiazine with alpha-blocking activity that can cause orthostatic hypotension. With lisinopril the blood pressure lowering may be increased.
How serious is the interaction between Lisinopril and Promazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when either drug is started or changed, particularly in older patients.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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