Drug interactions
Lisinopril + Salicylates
Severity: Moderate
Lisinopril and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at analgesic or anti-inflammatory doses can blunt the blood pressure lowering effect of lisinopril. Together they may also raise the risk of reduced renal function, especially in older patients, those who are volume depleted, or those with existing kidney disease.
What this interaction means in plain words
Lisinopril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis causes sodium and fluid retention and reduced renal vasodilation, opposing ACE inhibitor effects.
What to do
Monitor blood pressure and serum creatinine and potassium when salicylates are used regularly at higher doses, and keep patients hydrated. Prefer paracetamol for analgesia where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisinopril and Salicylates, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Salicylates?
MediHelp rates the interaction as moderate. Lisinopril and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at analgesic or anti-inflammatory doses can blunt the blood pressure lowering effect of lisinopril. Together they may also raise the risk of reduced renal function, especially in older patients, those who are volume depleted, or those with existing kidney disease.
How serious is the interaction between Lisinopril and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium when salicylates are used regularly at higher doses, and keep patients hydrated. Prefer paracetamol for analgesia where suitable.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
