Drug interactions
Lisinopril + Sodium bicarbonate
Severity: Minor
Lisinopril and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established interaction exists that would reduce lisinopril efficacy. Sodium load from large bicarbonate doses could theoretically blunt blood pressure control, but this is not a consistent or documented effect.
What this interaction means in plain words
Lisinopril and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisinopril belongs to Cardiovascular; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Not established; possible sodium and fluid retention with large bicarbonate doses.
What to do
No routine action needed; monitor blood pressure if high-dose or chronic bicarbonate therapy is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Lisinopril with Sodium bicarbonate?
MediHelp rates the interaction as minor. Lisinopril and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established interaction exists that would reduce lisinopril efficacy. Sodium load from large bicarbonate doses could theoretically blunt blood pressure control, but this is not a consistent or documented effect.
How serious is the interaction between Lisinopril and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed; monitor blood pressure if high-dose or chronic bicarbonate therapy is used.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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