Drug interactions
Lisinopril + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Lisinopril and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations can cause fluid loss and electrolyte shifts, leading to volume depletion. With lisinopril, this raises the risk of acute kidney injury and hypotension, and the potassium content may add to hyperkalemia risk.
What this interaction means in plain words
Lisinopril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep-induced volume depletion and electrolyte changes impair renal perfusion, which ACE inhibition makes less tolerable.
What to do
Ensure adequate hydration, consider holding lisinopril on the day of preparation in at-risk patients, and check renal function and electrolytes if symptomatic or high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Lisinopril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations can cause fluid loss and electrolyte shifts, leading to volume depletion. With lisinopril, this raises the risk of acute kidney injury and hypotension, and the potassium content may add to hyperkalemia risk.
How serious is the interaction between Lisinopril and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration, consider holding lisinopril on the day of preparation in at-risk patients, and check renal function and electrolytes if symptomatic or high risk.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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