Drug interactions
Lisinopril + Sulfasalazine
Severity: Minor
Lisinopril and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is not an NSAID and does not meaningfully inhibit renal prostaglandins, so the NSAID-type antagonism described does not apply. Any shared concern is rare kidney or blood toxicity, with no established interaction.
What this interaction means in plain words
Lisinopril and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism for interaction between these agents.
What to do
No specific action; monitor renal function and blood counts as routinely indicated for each drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Sulfasalazine?
MediHelp rates the interaction as minor. Lisinopril and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is not an NSAID and does not meaningfully inhibit renal prostaglandins, so the NSAID-type antagonism described does not apply. Any shared concern is rare kidney or blood toxicity, with no established interaction.
How serious is the interaction between Lisinopril and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action; monitor renal function and blood counts as routinely indicated for each drug.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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