Drug interactions
Lisinopril + Synthetic human angiotensin ii
Severity: Moderate
Lisinopril and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin II is given to raise blood pressure in vasodilatory shock, and ACE inhibitor use before treatment may increase the pressor response to it. Patients on lisinopril may therefore need a lower starting infusion rate.
What this interaction means in plain words
Lisinopril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition reduces endogenous angiotensin II, which may increase sensitivity to exogenous angiotensin II.
What to do
Titrate angiotensin II carefully from the lowest effective dose with continuous blood pressure monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Lisinopril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin II is given to raise blood pressure in vasodilatory shock, and ACE inhibitor use before treatment may increase the pressor response to it. Patients on lisinopril may therefore need a lower starting infusion rate.
How serious is the interaction between Lisinopril and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II carefully from the lowest effective dose with continuous blood pressure monitoring.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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