Drug interactions
Lisinopril + Trifluoperazine
Severity: Moderate
Lisinopril and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has alpha-adrenergic blocking properties that can cause orthostatic hypotension. Combined with lisinopril, blood pressure lowering may be enhanced, with risk of dizziness and falls.
What this interaction means in plain words
Lisinopril and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from phenothiazine alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure, especially orthostatic readings, after starting or changing doses. Counsel patients to rise slowly and adjust antihypertensive dosing if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Trifluoperazine?
MediHelp rates the interaction as moderate. Lisinopril and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine has alpha-adrenergic blocking properties that can cause orthostatic hypotension. Combined with lisinopril, blood pressure lowering may be enhanced, with risk of dizziness and falls.
How serious is the interaction between Lisinopril and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially orthostatic readings, after starting or changing doses. Counsel patients to rise slowly and adjust antihypertensive dosing if needed.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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