Drug interactions
Lisinopril + Xipamide
Severity: Moderate
Lisinopril and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide, a thiazide-like diuretic, adds to lisinopril's blood pressure lowering, which is often used intentionally. Volume depletion from the diuretic can cause marked first-dose hypotension and renal function decline.
What this interaction means in plain words
Lisinopril and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect from diuretic-induced volume and sodium depletion with renin-angiotensin system blockade.
What to do
Consider lowering or temporarily withholding the diuretic before starting lisinopril, and check blood pressure, creatinine and potassium after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Xipamide?
MediHelp rates the interaction as moderate. Lisinopril and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide, a thiazide-like diuretic, adds to lisinopril's blood pressure lowering, which is often used intentionally. Volume depletion from the diuretic can cause marked first-dose hypotension and renal function decline.
How serious is the interaction between Lisinopril and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering or temporarily withholding the diuretic before starting lisinopril, and check blood pressure, creatinine and potassium after initiation.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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