Drug interactions
Lisinopril + Zotepine
Severity: Moderate
Lisinopril and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine blocks alpha-1 adrenoceptors and can cause orthostatic hypotension, which may add to the hypotensive effect of lisinopril. Dizziness and falls may occur, particularly during dose initiation.
What this interaction means in plain words
Lisinopril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from antipsychotic alpha-1 adrenergic blockade and ACE inhibition.
What to do
Titrate zotepine slowly, monitor orthostatic blood pressure, and adjust the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Zotepine?
MediHelp rates the interaction as moderate. Lisinopril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine blocks alpha-1 adrenoceptors and can cause orthostatic hypotension, which may add to the hypotensive effect of lisinopril. Dizziness and falls may occur, particularly during dose initiation.
How serious is the interaction between Lisinopril and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate zotepine slowly, monitor orthostatic blood pressure, and adjust the antihypertensive dose if hypotension develops.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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