Drug interactions
Lisocabtagene maraleucel + Trastuzumab
Severity: Moderate
Lisocabtagene maraleucel and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisocabtagene maraleucel is a CD19-directed CAR T-cell therapy that causes prolonged cytopenias, B-cell depletion and infections. Trastuzumab may add marginally to this risk. Clinical data on the combination are lacking.
What this interaction means in plain words
Lisocabtagene maraleucel and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisocabtagene maraleucel belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Possible additive immune and hematologic toxicity; the interaction is largely theoretical.
What to do
Avoid giving trastuzumab around the time of CAR T infusion unless clearly needed. Monitor blood counts and for infection afterwards.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Lisocabtagene maraleucel
Frequently asked questions
Can I take Lisocabtagene maraleucel with Trastuzumab?
MediHelp rates the interaction as moderate. Lisocabtagene maraleucel and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisocabtagene maraleucel is a CD19-directed CAR T-cell therapy that causes prolonged cytopenias, B-cell depletion and infections. Trastuzumab may add marginally to this risk. Clinical data on the combination are lacking.
How serious is the interaction between Lisocabtagene maraleucel and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving trastuzumab around the time of CAR T infusion unless clearly needed. Monitor blood counts and for infection afterwards.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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